Building blocksQuires, which were produced by bundling together a number of bifolia, form the building blocks of the manuscript. How many bifolia the scribe bundled together often depended on his or her location. Book producers in England, for example, are known to have regularly produced quires of six bifolia, while scribes on the Continent typically preferred quires of four bifolia. Some quires are irregular. An extra folium could be added (called a singleton) or a leaf could be cut out.